The Hamilton and Waikato region has an extensive and well maintained roading network, including major state highways.

State Highway 1 passes through the region taking in picturesque towns such as Cambridge and Tirau as well as the city of Hamilton, and connecting it via expressway to Auckland in the north and Taupo in the south. State Highway 3 takes in Waitomo along with neighbours Otorohanga and Te Kuiti.

Most of the major rental car companies have offices in the city and at the airport. To make things even easier, Hamilton Transport Centre is the hub for bus and coach services, covering the city and region as well as all North Island destinations.